Some artificial intelligence (AI) startups engage with science, while others do not. Such engagement can distract from commercial goals or trigger disclosures, yet it may enable learning, network access, and legitimacy. We conceptualize scientific engagement as an entrepreneurial strategy during an industry’s incubation phase, characterized by weak appropriability and high technological opportunity. Using a unique dataset of UK AI startups, we measure engagement through multiple channels and document a positive association with valuation. Using a funding-sibling design—comparing startups backed by the same investor—we find engagement is associated with 19–32% higher valuations. This premium is stronger when startups engage across multiple channels. Finally, we explore how startup maturity and technology shocks shape this premium.